Mini-project
Pharma & Life Sciences
Tablet formulation by designed experiments
Find the best binder and disintegrant levels for a tablet using a designed experiment and a response surface.
The brief
Formulators often change one ingredient at a time and miss how ingredients interact. Plan a designed experiment (factorial or central composite) for binder and disintegrant levels, fit a model for hardness, friability and disintegration time, and find the region where every quality target is met. Good looks like: a proper design table, model checks, a contour plot of the design space and a recommended formula with a margin of safety.
What you will build
- Choose factors, levels and quality targets
- Build the experimental design
- Collect or simulate the responses
- Fit regression models and check them
- Plot contours and find the design space
- Recommend and justify a formula
Free, open data to build it with
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